Abstract
ObjectivesTo examine the effect of including buprenorphine with detomidine for sedation of horses undergoing clinical procedures. Study designPartially blinded, randomised, prospective clinical field trial. AnimalsEighty four client-owned horses scheduled for minor surgery or diagnostic investigation under standing sedation. MethodsThe effects of buprenorphine (5 μg kg−1) (Group B, n = 46) or placebo (5% glucose solution) (Group C, n = 38) in combination with detomidine (10 μg kg−1) were compared in standing horses undergoing minor clinical procedures. The primary outcome measure was successful completion of the procedure. The degree of sedation and ataxia were scored using simple descriptive scales. Heart and respiratory rates were recorded at 15–30 minute intervals. Parametric data from each group were compared using anova or t-test and non parametric data using the Mann–Whitney U test. ResultsThe procedure was carried out successfully in 91% of Group B and 63% of Group C (p < 0.01). Repeat dosing was required in 24% of Group B and 32% of Group C (p < 0.05). Sedation was more profound and lasted longer (60 versus 45 minutes) in Group B (p < 0.01). Ataxia occurred after detomidine, increased after buprenorphine but not glucose administration, was more profound in group B and lasted longer (60 versus 30 minutes) p < 0.001). Heart and respiratory rates remained within normal limits in both groups and there were no serious adverse events. Conclusions and clinical relevanceBuprenorphine 5 and 10 μg kg−1 enhanced the sedation produced by detomidine 10 and 20 μg kg−1 with minor side effects similar to other alpha2 agonist/opioid combinations. Detomidine–buprenorphine sedation is suitable for standing procedures in horses.
Highlights
Numerous diagnostic and minor surgical procedures are performed on sedated, standing horses because general anaesthesia carries a substantial risk of mortality and morbidity in this species (Johnston et al 2004)
Conclusions and clinical relevance Buprenorphine 5 and 10 lg kgÀ1 enhanced the sedation produced by detomidine 10 and 20 lg kgÀ1 with minor side effects similar to other alpha2 agonist/ opioid combinations
Detomidine–buprenorphine sedation is suitable for standing procedures in horses
Summary
Numerous diagnostic and minor surgical procedures are performed on sedated, standing horses because general anaesthesia carries a substantial risk of mortality and morbidity in this species (Johnston et al 2004). Detomidine-buprenorphine sedation in horses P Taylor et al. Acepromazine and the alpha adrenoceptor agonists are the most common individual agents used for chemical restraint, but it is well recognized that addition of an opioid enhances their sedative effects without seriously compromising vital function (Clarke & Paton 1988; Taylor & Clarke 2007). In the UK at least, detomidine or romifidine with butorphanol are probably the most commonly used for sedation from a simple bolus injection (Taylor et al 1988; Browning & Collins 1994).
Sign-in/Register to view highlights & summary Sign-in/Register to access full text options 
Talk to us
Join us for a 30 min session where you can share your feedback and ask us any queries you have
Schedule a callDisclaimer: All third-party content on this website/platform is and will remain the property of their respective owners and is provided on "as is" basis without any warranties, express or implied. Use of third-party content does not indicate any affiliation, sponsorship with or endorsement by them. Any references to third-party content is to identify the corresponding services and shall be considered fair use under The CopyrightLaw.
