Abstract

Evaluation of quantitative variation of secondary metabolites in Bergenia ciliata (Haw.) using high performance thin layer chromatography.

Highlights

  • Dear Editor: Therapeutically active metabolite contents in a medicinal plant vary in nature, which may impact on its therapeutic efficacy

  • We analyzed three accessions of Bergenia ciliata collected from different altitudes of Uttrakhand, India, to study the quantitative variation in bergenin, gallic acid, (+) catechin, and gallicin by high performance thin layer chromatography (HPTLC)

  • We found significant variations in the content of these compounds in the collected rhizomes of Bergenia ciliata ranging from 0.756¡0.3 to 0.85¡0.2 for bergenin, 0.145¡0.2 to 0.27¡0.2 for (+) catechin, 0.027¡0.2 to 0.166¡0.3 for gallic acid and 0.135¡0.3 to 0.186¡0.1 for gallicin

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Summary

Introduction

Dear Editor: Therapeutically active metabolite contents in a medicinal plant vary in nature, which may impact on its therapeutic efficacy. Its distribution over a wide range of altitudinal zones makes it a good candidate for studying variations in its metabolic profiles under different climatic conditions. Bergenin (C-glycoside of 4-O-methyl gallic acid) has been identified as a potent active secondary metabolite in Bergenia and other therapeutically active constituents including, among others, gallic acid (3,4,5 trihydroxybenzoic acid), (+) catechin, and gallicin (Fig. 1).

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