Abstract
Early onset infections are caused by organism prevalent in the maternal genital tract or in the delivery area. PROM is rupture of membranes before the onset of labour after 37 completed weeks of gestation. Intra amniotic infection is an acute inflammation of the membrane and chorion of the placenta, typically due to ascending polymicrobial bacterial infection in the setting of membrane rupture. Hence based on above conditions the present study was planned for Evaluation of Positivity of CRP test in early Onset Neonatal Sepsis in Relation to Duration of PROM vs PROM Delivery Interval (PDI).
 The present study was planned in Department of Pediatrics, Nalanda Medical College and Hospital, Patna, Bihar, India. The study was planned from November 2018 to June 2019. In the present study 50 mothers attended t antenatal clinic towards term pregnancy with history of leaking or confirmed PROM were enrolled. Clinical PROM was confirmed by speculum examination and the duration was recorded. All cases managed actively and the interval between PROM and delivery were recorded in obstetric unit of this hospital.
 The data generated from the present study concludes that even if 6 hour PROM is high risk for EONS, PDI should be considered first before PROM. So that, we will be more cautious and supportive and use of antibiotics in treatment to prevent need for neonatal intensive care without increase in perinatal morbidity and mortality.
 Keywords: Early onset Sepsis (EOS), C- Reactive Protein (CRP), Premature rupture of membrane( PROM) PROM delivery interval(PDI), etc.
Highlights
Neonatal sepsis may be categorized as early onset or late onset
Based on above conditions the present study was planned for Evaluation of Positivity of C- Reactive Protein (CRP) test in early Onset Neonatal Sepsis in Relation to Duration of premature rupture of membranes (PROM) vs PROM Delivery Interval (PDI)
Clinical PROM was confirmed by speculum examination and the duration was recorded
Summary
Neonatal sepsis may be categorized as early onset (day of life 0-3) or late onset (day of life 4 or later). Of newborns with early-onset sepsis, 85% present within 24 hours (median age of onset 6 hours), 5% present at 24-48 hours, and a smaller percentage present within 48-72 hours. Onset is most rapid in premature neonates. Early-onset sepsis is associated with acquisition of microorganisms from the mother. Infection can occur via hematogenous, transplacental spread from an infected mother or, more commonly, via ascending infection from the cervix. Organisms that colonize the mother’s genitourinary (GU) tract may be acquired by the neonate as it passes through the colonized birth canal at delivery. The microorganisms most commonly associated with earlyonset infection include the following [1] : Group B Streptococcus (GBS); Escherichia coli; Coagulase-negative Staphylococcus; Haemophilus influenza; Listeria monocytogenes
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