Abstract
Background and aim: Ameloblastic carcinoma is a rare malignant epithelial odontogenic tumour that histologically retains the features of ameloblastic differentiation and exhibits cytological features of malignancy in the primary or recurrent tumour. It may develop within a preexisting ameloblastoma or arise de novo or from an odontogenic cyst. Epidemiological evidence shows that human cancer is generally caused due to genotoxic factors. Genes involved in the susceptibility of cancer, including genes involved in metabolism or detoxification genotoxic environment and genes are controlling DNA replication.
Highlights
Gene polymorphism has an important role in development of malignant tumor .We report a case series study of ameloblastic carcinoma and ameloblastoma to show the role of PKM2 and MAPK8IP2 polymorphisms in these tumors
To assess whether PKM2 and MAPK8IP2 polymorphisms are associated with ameloblastic carcinoma, the patients with ameloblastic carcinoma were selected and compared to control individuals
The presence of PKM2 and MAPK8IP2 gene expression were determined by PCR in ameloblastoma and ameloblastic carcinoma comparing with normal follicle.c.37G>A polymorphism in PKM2 and the c.196C>T polymorphism in MAPK8IP2 were not recognized in all of the sample cases
Summary
Evaluation of PKM2 and MAPK8IP2 Polymorphism in Ameloblastic Carcinoma: A Retrospective Quantitative Study. Gene polymorphism has an important role in development of malignant tumor .We report a case series study of ameloblastic carcinoma and ameloblastoma to show the role of PKM2 and MAPK8IP2 polymorphisms in these tumors. The lack of clinical methods for identifying individuals with high risk of oral cancer, and to answer the question in the case of different responses of individuals to environmental carcinogens and differences in genetic predisposition, make importance of using genetic tests for ameloblastic carcinoma more understandable [9, 10]. The protein encoded by this gene is closely related to MAPK8IP1/IB1/JIP-1, a scaffold protein that is involved in the c-Jun amino-terminal kinase signaling pathway This pathway plays a role in inflammatory signal transduction. According to a variety of amloblastoma tumor and amloblastic carcinoma in terms of pathology as well as the symptoms of this tumor, it seems that the cellular and molecular processes which contribute to its division could offer early detection along with exclusive treatments strategy [18,19,20]
Sign-in/Register to view highlights & summary Sign-in/Register to access full text options 
Talk to us
Join us for a 30 min session where you can share your feedback and ask us any queries you have
Schedule a callMore From: International Journal of Oral & Maxillofacial Surgery
Disclaimer: All third-party content on this website/platform is and will remain the property of their respective owners and is provided on "as is" basis without any warranties, express or implied. Use of third-party content does not indicate any affiliation, sponsorship with or endorsement by them. Any references to third-party content is to identify the corresponding services and shall be considered fair use under The CopyrightLaw.
