Abstract
Purpose: Cartilage degeneration in osteoarthritis (OA) is characterized by a change in the chondrocyte phenotype toward hypertrophic differentiation, that leads to elevated production of proteolytic enzymes and consequently to cartilage damage and loss of joint function. The presence of relevant biomarkers in synovial fluid or serum, such as inflammation biomarkers or matrix metalloproteinases, together with observation by magnetic resonance imaging, have been described as defining parameters in OA diagnosis.
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