Abstract
BackgroundThe goal of present study is to examine comparatively the epithelium of oral mucosa in persons with diabetes types I and II and the healthy persons by cytomorphometric method.MethodsCytology smear was prepared from oral mucosa epithelium in 24 persons with diabetes and 30 healthy persons were stained by papanicolao method. Its before, from patients were requested acquiring written. The quantitative cytomorphometric characteristics were measured in each group by motic plus 2 software. Also, the qualitative evaluation of cytology slides are performed in three groups.ResultsThere were decrease in the nuclear and cytoplasmic size, (P < 0.001) and increase in the ratio of nuclear to cytoplasm size in buccal mucosal areas (P = 0.001) and tongue (P = 0.011) of diabetic persons compared to the healthy persons. There was no significantly statistical difference in diabetic persons types I and II in buccal mucosal area (P = 0.15) and tongue (P = 0.86) in quantitative characteristics of cytomoerphometry. In nuclear and cytoplasm size, there was a significant statistical difference in persons with diabetes type I and persons of control I and persons with diabetes type II and persons of control II in buccal mucosa and the tongue (P < 0.001). Bilobed or multi-lobed nuleous, karyorrhexis and vacuolization of cytoplasm were more in diabetic persons compared to the healthy ones (P < 0.001).ConclusionDiabetes are effective in creating some quantitative and qualitative cytometric alterations in the oral mucosa but the type of diabetes doesn’t seem to be effective on these changes.
Highlights
Diabetes mellitus is a complex metabolic disease which is followed by disorders in the metabolism of carbohydrate, lipid and protein [1]
In terms of age, there was no significant difference between persons with diabetes type I and those of control I and persons with diabetes type II and those of control II (P = 0.1 ) (Table 1)
-There was no statistically significant difference in terms of the ratio of nuclear to cytoplasm in tongue region in persons with diabetes type I and those of control I (P = 0.21) and persons with diabetes type II and those of control II (P = 0.39) (Table 4)
Summary
Diabetes mellitus is a complex metabolic disease which is followed by disorders in the metabolism of carbohydrate, lipid and protein [1]. It’s incidence is increasing in developing countries [2] and mortality is resulted from this disease in the performance of vascular system and default in the activity of kidneys [3]. It includes diabetes types I and II, gestational diabetes and diabetes type 1.5 or double type. Diabetes in the performance of oral mucosa due to the substitution and change in the salivary amount and change in the kind of nutrition and decrease in the activity most common cytology technique for smear staining [10]. The goal of present study is to examine comparatively the epithelium of oral mucosa in persons with diabetes types I and II and the healthy persons by cytomorphometric method
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