Abstract
<h3>Objectives</h3> To analyze mast cell concentrations and degranulation and mononuclear inflammatory cell concentrations in cases of oral lichen planus (OLP) and oral lichenoid reaction associated to amalgam restoration (LRA). <h3>Study Design</h3> Six tissue samples diagnosed with OLP, 7 diagnosed with LRAs, and 6 fragments of healthy oral mucosa were immunostained for anti-c-Kit and anti-tryptase and submitted to toluidine blue reactions. <h3>Results</h3> The density of c-Kit+, tryptase+, and toluidine blue+ mast cells in OLP and LRA was higher than that in healthy oral mucosa (<i>P</i> < .05). Also, mononuclear inflammatory cell concentrations were higher in OLLs than in OLP (<i>P</i> < .05). <h3>Conclusions</h3> Mononuclear inflammatory cells are relevant and may contribute to differentiate OLP from LRA. Regardless of statistical inconsistency in quantitative analysis, mast cells are well stablished in the etiopathogenesis of OLP and LRA.
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