Abstract
Models for the evaluation of interaction in olfactory and taste mixtures are compared to the isobole approach, which is widely used in other fields of bioraedical research. Analogies and differences are described in detail. The isobole approach has a profound theoretical basis and can be applied to all possible types of concentration-response relationships, in particular to all values of exponents in the widely used power function, and even if analytical expression of concentration—response relationships are not known. Due to this generality it leads to a substantial simplification of the evaluation procedures as compared to other methods used in taste and olfaction research. It can be applied to any number of components of a mixture. Response surface modeling and computer graphics is recommended in appropriate cases because it can provide information on the concentration dependence of interaction. Even though it has to be pointed out that there is no general consensus on the most appropriate approach for the evaluation of interaction between biologically active agents so far, we are led to the conclusion that good arguments can be made in supporting the application of the isobole method for taste and olfactory mixtures.
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