Abstract
Indomethacin-loaded polymethylmethacrylate microparticles were prepared from an aqueous system by the emulsion–solvent evaporation method, and evaluated with respect to in-vitro drug release and physical characteristics of the microparticles. At a constant drug load, variation in the concentration of methylcellulose, used as emulsion stabilizer during the preparation of the microparticles, did not cause any significant change in drug release. However, drug load and size of the microparticles did influence the drug release profiles considerably. Preliminary investigations using IR, X-ray diffraction and differential scanning calorimetry revealed that drug–polymer interactions or polymorphic changes in the drug did not occur in the microparticles. This study indicates that polymethylmethacrylate microparticles could be used as a polymer for a controlled-release dosage form of indomethacin.
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