Abstract
BackgroundIt is important to devise efficient and easy methods of detecting colorectal tumours to reduce mortality from colorectal cancer. Dual-wavelength excitation autofluorescence intensity can be used to visualize colorectal tumours. Therefore, we evaluated dual-wavelength excitation autofluorescence images of colorectal tumours obtained with a newly developed, high-sensitivity complementary metal-oxide-semiconductor (CMOS) imager.MethodsA total 107 colorectal tumours (44 adenomas, 43 adenocarcinomas with intramucosal invasion, and 20 sessile serrated adenoma/polyps [SSA/Ps]) in 98 patients who underwent endoscopic tumour resection were included. The specimens were irradiated with excitation light at 365 nm and 405 nm, and autofluorescence images measured with a 475 ± 25-nm band pass filter were obtained using a new, high-sensitivity CMOS imager. Ratio images (F365ex/F405ex) were created to evaluate the lesion brightness compared with that of normal mucosa, and specimens were categorized into a no signal or high signal group.ResultsAdenomas and adenocarcinomas were depicted in 87 ratio images, with 86.2 % (n = 75) in the High signal group. SSA/P was depicted in 20 ratio images, with 70.0 % (n = 14) in the High signal group.ConclusionsDual-wavelength excitation autofluorescence images of colorectal tumours can be acquired using our high-sensitivity CMOS imager, and are useful in detecting colorectal tumours.
Highlights
It is important to devise efficient and easy methods of detecting colorectal tumours to reduce mortality from colorectal cancer
Adenomas and adenocarcinomas were depicted in 87 ratio images, with 86.2 % (n = 75) in the High signal group
We further evaluated the appearance of the adenomas and adenocarcinomas and sessile serrated adenoma/polyp (SSA/P) according to the macroscopic type
Summary
It is important to devise efficient and easy methods of detecting colorectal tumours to reduce mortality from colorectal cancer. Dual-wavelength excitation autofluorescence intensity can be used to visualize colorectal tumours. We evaluated dual-wavelength excitation autofluorescence images of colorectal tumours obtained with a newly developed, high-sensitivity complementary metal-oxide-semiconductor (CMOS) imager. Because most adenomas are premalignant lesions, elimination of colon adenoma is an effective strategy for preventing colon cancer development, and several studies have reported that endoscopic resection of colon adenoma decreases colon cancer mortality. Serrated colorectal lesions are considered precursors for up to one-third of colorectal cancers. Sensitive detection of adenomas would contribute to risk prediction and to the Fluorescence emission, known as autofluorescence, is an intrinsic property of cells that is caused by endogenous fluorophores.
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