Abstract

It is widely known that diabetes is a risk factor for dementia. It has been reported that the cognitive function is impaired in the streptozotocin (STZ)-induced diabetic mouse model. Recently, it has also been reported that alteration of the intestinal flora is a risk factor for dementia. However, effects of alteration of the intestinal flora due to dementia on the cognitive function have not been adequately assessed. One of the reasons is that germ-free mice, which have no intestinal flora, need to be housed in a germ-free environment. Therefore, it is difficult to subject to behavioral tests in a germ-free environment to assess the cognitive function.

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