Abstract
Isatin reacted with formaldehyde and a number of secondary amines in order to produce the N-Mannich bases of isatin derivatives. FT-IR, 1H-NMR, and mass spectrum data were used to demonstrate that their chemical structures were accurate. An agar diffusion method was used to examine the antibacterial activity of compounds against Gram (+) bacteria (Staphylococcus aureus and Micrococcus luteus) and Gram (-) bacteria (Escherichia coli and Klebsiella pneumonia), with streptomycin employed as control. The antifungal activity of fluconazole against Candida albicans and Aspergillus niger was measured against a benchmark of fluconazole's own performance. Compounds IVc, IVd, and IVe all exhibited potent antibacterial activity, but only compounds IVc and IVd were effective against fungal infections. Compounds IVc and IVe were found to have the highest potential as anti-oxidants among the chemicals that were investigated.
Talk to us
Join us for a 30 min session where you can share your feedback and ask us any queries you have
More From: International Journal of Zoological Investigations
Disclaimer: All third-party content on this website/platform is and will remain the property of their respective owners and is provided on "as is" basis without any warranties, express or implied. Use of third-party content does not indicate any affiliation, sponsorship with or endorsement by them. Any references to third-party content is to identify the corresponding services and shall be considered fair use under The CopyrightLaw.