EVALUATION OF ANTI EPILEPTIC ACTIVITY OF ETHANOLIC EXTRACT OF MURRAYA KAENIGII ON MES, PTZ INDUCED CONVULSIONS IN RATS

Abstract

The aim of the study was to evaluate anti epileptic activity of ethanolic extract of M. kaenigii on MES, PTZ Induced convulsions in Rats. After the collection of the plant it was extracted with using ethanol solvent by maceration method. Preliminary Phytochemical analysis was done. Acute toxicity was studied. Assessments of antioxidant activity by assay of superoxide dismutase were done and also different enzyme analysis was studied. Effect of EEMK on ME induced convlusions was done in PHT treated animals. Secondary metabolites including alkaloids, saponins, cardiac glycosides and flavonoids were found to be present in the extract and these could have a wide range of compounds with pharmacological activities including those found in this study. Effect of antioxidant enzymes on MES and PTZ induced convolutions were studied. EEMK significantly inhibited the PTZ-induced convulsion, prolonged the latency for convulsion and decreased mortality. The PTZ kindling model is a widely used screening model for testing anticonvulsive compounds. Results based on the PTZ induced clonic seizures and MES induced generalized clonic-tonic seizures in rats model demonstrated that the ethanol extract of Murraya koenigii - Linn. is effective in reducing the severity of clonic seizures and generalized clonic-tonic seizures. This, therefore, supports the traditional use of the plant in the treatment of epilepsy.