Abstract
Studies were undertaken to evaluate the efficacy of purified lichen extracts against cancer induced Albino wistar rats as an animal model under in vivo condition. Lichen species were collected from different mean sea level of Yercaud hills of Tamil Nadu, India. Extraction and purification of lichen compounds were done using silica gel column chromatography with TLC analysis. Different fractions were collected from the crude extract and it was subjected to study the potential of anticancerous property. Anticancer activity was confirmed that Parmotrema reticulatum exhibited the highest control over the cervical cancer in cell line model. The compound Benzoic acid, 2, 4 dihydroxy, 6 methyl-methyl ester was identified as a potent molecule from Rocella montagnei. Anticancer effect of P. reticulatum and P. hababianum and their compounds were further evaluated to have the effective cancer drug against cervical cancer disease. Cancer cell line induced rats showing a significant reduction tumor proliferation which were treated with bioactive anti-cancer lichen compounds in comparison with the standard drug. Histopathology and hematology studies have been done to examine to confirm the level of tumor growth in the animals and to analyze the blood platelet count in tumors; respectively.
Highlights
Cancer is of paramount importance today in terms of third leading cause of cancer-related death worldwide to human beings [1]
The rich and diverse plant sources of India are likely to provide effective anti-cancer agents. It is of the best approaches in the search for anticancer agents from plant resources is the selection of plants based on ethnomedical leads [5]
The high genus level of appearance was observed as parmeliod lichen species at Yercaud and Kolli hills which was used for extraction of bioactive anticancer compounds for the present study
Summary
Cancer is of paramount importance today in terms of third leading cause of cancer-related death worldwide to human beings [1]. It develops because of the progressive accumulation of genetic and epigenetic alterations in human body cells that lead to the transformation of normal colonic epithelium to colon adeno carcinoma. The rich and diverse plant sources of India are likely to provide effective anti-cancer agents. It is of the best approaches in the search for anticancer agents from plant resources is the selection of plants based on ethnomedical leads [5]
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