Abstract
Dextran sulfate sodium (DDS)-induced acute colitis in C57BL/6 mice is essential for several research aspects, but the inducing condition should be optimized with the purpose of different study. In this study, C57BL/6 mice drank water with 5 (w/v) % DSS dissolved for 7 days to induce acute colitis, which were evaluated from three aspects, including body weight change, colon length and histopathological changes. On day 8, the inflammation response to DSS treatment showed in the colon of C57BL/6 mouse. Compared with the control group, 5% DSS treatment decreased the weight of mice after drinking for 3 days, with Disease activity index (DAI) score corresponding to the pathological manifestations (p < 0.001). The colons were shorter significantly (p < 0.001) compared with control group. Partial colon of DSS-treated mice under H&E staining displayed severe inflammatory manifestations. In conclusion, this study constructed a successful acute colitis model, which can be a reference for others to do some studies related.
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