Abstract
Perioperative anaphylaxis presents a diagnostic challenge for allergists because surgical patients often have been exposed to several agents during a short period. One particularly complex scenario is anaphylaxis during procedures involving sentinel lymph node biopsies. Isosulfan blue is a triphenylmethane dye routinely used in sentinel lymph node biopsy procedures during breast cancer and melanoma surgeries.1 Anaphylaxis to isosulfan blue is estimated to complicate 1% to 3% of sentinel lymph node biopsy procedures, making it an uncommon but clinically significant adverse event.
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