Abstract
In this study a rotating filter was evaluated using a two-dimensional convective diffusion model. Experimental model testing involved analysis of dissolution rates from non-disintegrating salicylic acid discs. For each dissolution run the disc was positioned at the bottom of the dissolution container. The tablets were coated so only a single salicyclic acid face on the side facing the stirrer was exposed for dissolution. Experimental variables included stirring speed, tablet radius and the distance of the tablet from the center of the container. From the data and visualization studies liquid flow inside the dissolution fluid container was described. The single-faced salicylic acid tablets proved to be an excellent system with which to test the convective diffusion model. The results seem to support the proposed convective diffusion theory which indicates the numerical exponents for stirring speed and tablet radius are 0.5 and 1.5, respectively.
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