Abstract
Evaluation of a human placenta-derived hydrogel to support glucose sensitive insulin secretion in human donor islets
Highlights
Diabetes is an evolving worldwide health concern
Human extracellular matrix (HuECM) is a protein-rich matrix derived from human placenta
A rapid decline of islet viability and loss of stimulus-induced insulin secretion remains a major challenge for investigations involving primary human pancreatic islets in culture [1,2,16]
Summary
Diabetes is an evolving worldwide health concern. While it is a complex disease, diabetes principally arises from a failure of function in the pancreatic islet beta cell. Access to human islets is limited and compounded since human islets loose function rapidly and do not survive beyond a few days when cultured ex vivo [1,2]. Development of new modalities to culture human islets to promote longer term survival and function is required. Better understanding of the interaction between pancreatic islets and their local microenvironment could contribute to advances in diabetic therapies [6,7]. The ability to preserve ECM-human islet interaction may enhance islet culture techniques to promote survival and maintenance of functional islets
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