Evaluation Effective Low-Volume Cardioplegia By «Custodiol» Solution

Abstract

Objectives. The study presents the results of quality assessment of antiischemic myocardial protection by low-volume method of cardioplegia by Custodiol solution during operations with cardiopulmonary bypass. Material and Methods. The study involved 57 patients who underwent different cardiosurgery operations with cardiopulmonary bypass. The patients were divided into two groups on the basis of the volume of cardioplegic solution. Research group (group 1) consists of 33 patients who were administered Custodiol in low volume limited by 1000 ml. The control group (group 2) consists of 24 patients who were administered standart volume of the solution corresponding to the manufacturer’s instructions: 1 ml per 1 g of myocardial mass during 6–8 minutes. Results. The volume of Custodiol administered per 1 kg of body weight was 12.7 ± 2.0 and 22.7 ± 4 ml and 4.0 ± 1.3 and 6.3 ± 1.9 ml per 1 g of myocardial mass in groups 1 and 2, respectively (p < 0.001). The frequency of catecholamines usage, temporary cardiac pacing and other adverse events with a small-volume cardioplegia technique with Custodiol solution did not differ significantly. The results has indicated that the use of low volume of cardioplegic Custodiol in a single administration manner provides a complete antiischemic protection of the myocardium during the correction of valvular heart disease, including combination with coronary artery bypass grafting. Conclusion. Usage of low volume Custodiol solution method does not increase the need of inotropic and vasopressor usage and pacing time.