Abstract
(1) Background: By 2050, it is estimated that 130 million people will be diagnosed with dementia, and currently approved medicines only slow the progression. So preventive intervention is important to treat dementia. Mild cognitive impairment is a condition characterized by some deterioration in cognitive function and increased risk of progressing to dementia. Therefore, the treatment of mild cognitive impairment (MCI) is a possible way to prevent dementia. Angelica gigas reduces neuroinflammation, improves circulation, and inhibits cholinesterase, which can be effective in the prevention of Alzheimer’s disease and vascular dementia and the progression of mild cognitive impairment. (2) Methods: Angelica gigas (AG) extract 1 mg/kg was administered to mildly cognitive impaired mice, models based on mild traumatic brain injury and chronic mild stress. Then, spatial, working, and object recognition and fear memory were measured. (3) Result: Angelica gigas improved spatial learning, working memory, and suppressed fear memory in the mild traumatic brain injury model. It also improved spatial learning and suppressed cued fear memory in the chronic mild stress model animals. (4) Conclusions: Angelica gigas can improve cognitive symptoms in mild cognitive impairment model mice.
Highlights
Mild cognitive impairment (MCI) refers to a condition in which one’s cognitive function is lower than that of normal peers but not considered dementia [1,2]
We investigated whether Angelica gigas (AG) extract could prevent the progression of cognitive decline or improve memory in MCI models
We found that AG improved spatial learning and working memory but suppressed fear memory in the Traumatic brain injury (TBI) model
Summary
Mild cognitive impairment (MCI) refers to a condition in which one’s cognitive function is lower than that of normal peers but not considered dementia [1,2]. Patients with MCI have an approximately 50% chance of developing Alzheimer’s disease within five years [3]. It is important to prevent MCI from progressing into dementia. There is no established treatment that prevents the progression of MCI to dementia [4].
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