Evaluating the Efficacy of Steroids in Autoimmune Disorders: A Comprehensive Review of Case Studies in Rheumatoid Arthritis, Lupus, and Asthma

Abstract

This comprehensive review evaluates the efficacy of corticosteroids in managing three prominent autoimmune disorders: rheumatoid arthritis (RA), systemic lupus erythematosus (SLE), and asthma. Autoimmune disorders are characterized by the immune system’s misdirected attack on healthy tissues, leading to chronic inflammation and debilitating symptoms. Corticosteroids have long been recognized as key therapeutic agents due to their potent anti-inflammatory and immunosuppressive properties. This review synthesizes findings from various case studies and clinical trials, highlighting the benefits of corticosteroids in reducing disease activity and improving patient outcomes across these conditions. However, the long-term use of corticosteroids is associated with significant adverse effects, including osteoporosis, metabolic disturbances, and increased infection risk, which complicate their clinical management. The review also discusses emerging treatment strategies aimed at minimizing steroid dependence, including combination therapies with disease-modifying agents and biologics. By examining the nuanced balance between the therapeutic benefits and potential risks of corticosteroids, this review aims to inform future research and clinical practices in the management of autoimmune disorders. Keywords: Corticosteroids, autoimmune disorders, rheumatoid arthritis, systemic lupus erythematosus, asthma