Abstract
1,25(OH)2D3 is a steroid hormone that plays a role in early gestation. One of its effects is to modulate the immune response, promoting a shift away from Th-1 to a Th-2 response, which is required to sustain pregnancy. The efficiency of decidual 1,25(OH)2D3 production depends on the availability of its precursor, 25(OH)D3. Therefore, a deficiency of vitamin D may have adverse effects on both immune activity and gene regulation at the fetal-placental interface, potentially increasing the chance of miscarriage.
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