Evaluating of Serum Electrolyte Changes in Chronic Renal Failure Pre and Post Dialysis

Abstract

Background: The kidney playedvital role in the regulation of electrolyte and acid–base balance. Withprogressive loss of renal function, derangements in electrolytes and acid–base certainlyoccurred andcontribute to worse patientoutcomes.Objective: The aim of the present study is to assess the effect of Hemodialysis (HD) on serum electrolyteslevels which compared with healthy controlgroup; also to assess the correlation of serum electrolyte beforeand after hemodialysis.Material and Method: The study done on 40 patients (25 men and 15 women) all patients with chronickidney disease, ages of patients 25 – 65 years. All patients enter the dialysis department in Merjan teachinghospital and matched with 30 well persons as control. Results: study of comparison between patients beforeand after hemodialysis, significant difference in the level of serum urea and creatinine between pre andpost dialysis, and significant effect of Hemodialysis on serum electrolytes particularly serum potassiumlevels. The pre-hemodialysis K+ was 4.48± 0.83 mmol/L and post-hemodialysis K+ was 3.69±0.65 mmol/L(P<0.001). The pre-hemodialysis Na+ was136.5±4.14 and post - hemodialysis Na+ was 138.6 ±4.41 (P = 0.36). The pre- hemodialysis Cl-was 106.12 ± 4.02 and post-hemodialysis Cl-was 107.12 ± 4.11 (P= 0.38NS).Conclusion: There is decrease in s. urea besides creatinine level between period before and afterhemodialysis.Serum K+ level decreased after hemodialysis. Although serum sodium and chloride levels not significantlyaffected after hemodialysis.