Abstract
Helleborus cyclophyllus is an ancient pharmaceutical plant that exhibits remarkable in vitro cytotoxic activity against malignant cell lines. In the present study, we evaluated the cytotoxic activity of Helleborus cyclophyllus dried powdered rhizome’s aqueous extract in both malignant (PC3, TPC1, K1 ) and normal ( Nthy-ori 3.1) cell lines. Our results demonstrated a promising therapeutic window, as normal cell lines exhibited significantly higher (x 10) IC50 than malignant cell lines. Gastric acid did not adversely affect Helleborus cyclophyllus extract’s cytotoxic activity as previous incubation in 1.0 M HCl acid did not result in IC50 values escalation. Finally, high extracellular lactic acid concentration resulted in Helleborus cyclophyllus extract’s cytotoxic activity amplification, whereas the presence of sodium lactate adversely affected cytotoxicity, revealing a possible indirect potential role for aerobic glycolysis to the clinically observed inadequacy of per os Helleborus cyclophyllus administration in cancer treatment.
Sign-in/Register to access full text options 
Talk to us
Join us for a 30 min session where you can share your feedback and ask us any queries you have
Schedule a callMore From: International Journal of Complementary & Alternative Medicine
Disclaimer: All third-party content on this website/platform is and will remain the property of their respective owners and is provided on "as is" basis without any warranties, express or implied. Use of third-party content does not indicate any affiliation, sponsorship with or endorsement by them. Any references to third-party content is to identify the corresponding services and shall be considered fair use under The CopyrightLaw.
