EVALUATING COMMON HEMATOLOGICAL AND BIOCHEMICAL BIOMARKERS AS PREDICTORS FOR ISCHEMIC HEART DISEASES AMONG ADULT SUDANESE PATIENTS

Abstract

Background: Ischemic heart diseases are the leading cause of death worldwide. It accounts for (20.07%) of total deaths with a death rate of 279.01 per 100.000 population. Being multifactorial in origin, the causes, diagnosis, prevention, control, and/or treatment of IHD remain active fields of biomedical research with considerable emphasis on the relativity of various risk factors and IHD. Methods: This is a descriptive cross-sectional case-control prospective analytical study to evaluate the hematological and biochemical predictors in ischemic heart disease patients in Shendi locality, River Nile, State Sudan. The study excluded all patients with comorbidities that might affect the results of biomarkers. Results: The mean values of Hb, PCV, RBCs, MCV, MCH, MCHC, RDW in case group were (12.3 g/dl), (37.7%), (4.2x1012/l), (87.9 fl), (28.9 pg), (32.9 g/dl) and (16.5) respectively and mean of TWBCs, Neutrophil, lymphocyte, monocyte, eosinophil, basophil, platelet count and MPV of (8.4 x 109 /l), (66.6%), (25%), (5.9%), (2.5%), (0%), (301.9 x 109 /l) and (8.4) respectively. The mean of hsCRP, D.dimer in case group were (5.896 mg/l), (1247.4 ng/ml), respectively. The case group had mean range of urea and creatinine (57.68 mg/dl) and (1.55 mg/dl) respectively, and mean of (Na+), (K+) and (Ca2+) of (136.1 mmol/l), (3.87 mmol/l) and (9.73 mg/dl) respectively. Conclusion: When compared to healthy individuals in the control group, the case group had lower Hb, PCV, red cells indices, serum sodium (Na+), potassium (K+), and calcium (Ca2+) levels. And higher levels of TWBCs, Neutrophil, platelet, MPV, Serum hsC-reative protein, plasma D.dimer, b.urea, and serum creatinine