Abstract
EUS-guided celiac plexus neurolysis (CPN) and celiac plexus block (CPB) are safe and at least as effective as percutaneous approaches. EUS-guided CPN is particularly effective for pain related to malignant involvement of the celiac ganglia. For patients without cancer, CPB is generally used instead but appears to be less effective. Given the different injectates, needles, and techniques that are available, there are many possible ways to perform the procedure. Further studies are needed to clarify the most effective way to perform the technique and to determine the optimal place for it in the therapeutic algorithms.
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