International Journal of Ophthalmology | VOL. 15
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Etiology, pathogenesis, and diagnosis of neovascular glaucoma

Publication Date Jun 18, 2022

Abstract

Neovascular glaucoma is defined as iris and/or anterior chamber angle neovascularization associated with increased intraocular pressure. It is a secondary glaucoma that is most frequently caused by severe retinal ischemia. The most common diseases responsible for the development of neovascular glaucoma are diabetic retinopathy, ischemic central retinal vein occlusion, and ocular ischemic syndrome. Uncommon causes include ocular radiation, ocular tumors, uveitis and other miscellaneous conditions. Vascular endothelial growth factor is an important and likely predominant agent involved in the pathogenesis of intraocular neovascularization and neovascular glaucoma. The evolution of clinical and histopathological changes from predisposing conditions to the occurrence of rubeosis iridis and neovascular glaucoma is divided into four stages: prerubeosis, preglaucoma, open angle glaucoma, and angle-closure glaucoma.

Concepts
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Neovascular Glaucoma
Ischemic Central Retinal Vein Occlusion
Severe Retinal Ischemia
Vascular Endothelial Growth Factor
Ocular Ischemic Syndrome
Angle-closure Glaucoma
Miscellaneous Conditions
Ocular Tumors
Secondary Glaucoma
Uncommon Causes

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