Abstract
PurposeTo estimate the etiology and features of the eyes with rubeosis iridis among Korean patients.Materials and MethodsThis study is a retrospective review of 533 Korean patients with rubeosis iridis who visited an eye hospital in Seoul, Korea. We defined rubeosis iridis as visible blood vessels on the iris surface detected during a slit-lamp examination. All cases were reviewed for age at the time of diagnosis, medical history, the most likely cause of rubeosis iridis, visual acuity, and intraocular pressure.ResultsThe most commonly observed cause of rubeosis iridis was diabetic retinopathy (DR; n = 337, 63.2%), followed by retinal vein occlusion (RVO; n = 101, 18.9%), ocular ischemic syndrome (OIS; n = 24, 4.5%), retinal detachment (n = 17, 3.2%), and uveitis (n = 15, 2.8%). The cause was classified as miscellaneous in 18 cases (3.4%); in 21 eyes (3.9%), the cause was not clear. Age at the time of rubeosis iridis diagnosis was lower in patients with DR (56.5 years) than in those with RVO (61.0 years) and OIS (64.8 years; P < 0.01). Intraocular pressure of the eyes with DR (37.3 mmHg) and RVO (39.5 mmHg) was higher than that of the eyes with OIS (25.8 mmHg; P < 0.01).ConclusionIn our population-based single center study, DR was the leading cause of rubeosis iridis followed by RVO and OIS among Korean patients. The clinical characteristics of the eyes with rubeosis iridis differed according to etiology. This finding may be useful when assessing eyes with rubeosis iridis.
Highlights
Neovascular glaucoma (NVG) is secondary glaucoma that can lead to serious visual impairment
Age at the time of rubeosis iridis diagnosis was lower in patients with diabetic retinopathy (DR) (56.5 years) than in those with retinal vein occlusion (RVO) (61.0 years) and ocular ischemic syndrome (OIS) (64.8 years; P < 0.01)
In our population-based single center study, DR was the leading cause of rubeosis iridis followed by RVO and OIS among Korean patients
Summary
Neovascular glaucoma (NVG) is secondary glaucoma that can lead to serious visual impairment. Brown et al [10] reported that RVO (36.1%) was the most common cause of NVG among US patients, followed by DR (32.2%) and carotid artery occlusion (12.9%). Based on these results, it is generally accepted that DR, RVO, and other diseases, including ocular ischemic syndrome (OIS), account for approximately onethird of the etiologic factors of NVG. Liao et al [16] reported that in China, DR was the leading cause (39.7%) of NVG, followed by RVO (22.9%) These findings suggest that the etiology of NVG may vary among populations. This study was performed to investigate the etiology and clinical features of eyes with rubeosis iridis among Korean patients who visited an eye hospital in Seoul, Korea
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