Abstract
Renal tubular oxalosis is a striking and regular phenomenon following the ingestion of ethylene glycol by a variety of mammals, including man. Doubt exists, however, regarding the relation of renal oxalate crystal formation to the mechanism of ethylene glycol toxicity. It has been proposed that the toxicity of ethylene glycol may be related either to a direct effect of the unaltered compound or to the production of toxic intermediaries in the course of degradation. The identification of glycolaldehyde, glycolic, and glyoxylic acid as probable intermediaries by Gessner and associates prompted the following experiment, in which the genesis of renal tubular oxalosis following the administration of these compounds was sought as an indicator of the validity of their place in the sequential degradation of ethylene glycol.
Sign-in/Register to access full text options 
Talk to us
Join us for a 30 min session where you can share your feedback and ask us any queries you have
Schedule a callDisclaimer: All third-party content on this website/platform is and will remain the property of their respective owners and is provided on "as is" basis without any warranties, express or implied. Use of third-party content does not indicate any affiliation, sponsorship with or endorsement by them. Any references to third-party content is to identify the corresponding services and shall be considered fair use under The CopyrightLaw.
