Abstract
Organelles are essential in maintaining homeostasis of mammalian cells. Monitoring the morphology and dynamics of organelles is of significance in cell state determination and disease diagnosis. We describe here a new material called ethyl violet-bovine serum albumin fluorescent protein nanovessel (EV-BSA FPN). Upon heating, BSA was denatured to form higher polyhedral structures, which was prone to EV binding. These dye-protein hybrid materials were red fluorescence emissive upon excitation. EV-BSA FPNs can be readily internalized by mammalian cells and dual localized in lysosomes and mitochondria. Besides, EV-BSA FPN can serve as carriers and efficiently deliver drug into cells. EV-BSA FPNs can be dual function fluorescent vessels for both dual-organelle imaging and drug delivery.
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