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Abstract
The ethanolic crude extract of Valeriana wallichii rhizome (VwR.Cr) was studied in vitro for its possible antispasmodic activity to rationalize some of its folkloric uses. Segments of 2-3 cm long of rabbit jejunum preparations were mounted in Tyrode’s solution and aerated with 95% oxygen in carbon dioxide. Isotonic responses were measured on Bioscience oscillograph. VwR.Cr caused a dose-dependent (0.1-3.0 mg/mL) relaxation of spontaneous contractions of isolated rabbit jejunum. When tested against high K+ (80 mM) induced contraction, it was found devoid of any inhibitory effect up to the dose of 10.0 mg/mL, while it inhibited the low K+ (25 mM)-induced contractions at the dose range of 0.1-1.0 mg/mL. In the presence of glibenclamide (3 µM), the dose-response curves of low K+ (25 mM) were shifted to the right. These data indicate that VwR.Cr exhibits spasmolytic activity mediated possibly through the opening of glibenclamide-sensitive K+ channels, which may explain the traditional use of the Valeriana wallichii in the gastrointestinal disorders, like diarrhea and spasmodic conditions.
Published Version
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