Abstract
Background: The interleukin‐1 receptor antagonist (IL‐1RA) plays an important role in bone metabolism, and molecular defects are implicated in the pathogenesis of osteoporosis. Studies performed in Caucasian populations have demonstrated an association between allelic variants of the IL‐1RA gene and bone mineral density (BMD).Methods: In the study reported here, we examined whether variation of the IL‐1RA gene would correlate with osteoporosis among 287 Japanese postmenopausal women.Results: The allele frequencies and distribution in this ethnic group were remarkably different from those reported for Caucasians and phenotypes such as Z scores of lumbar spine (L2–4) and total body BMD, as well as various biochemical markers related to bone metabolism, were not significantly different among groups of IL‐1RA genotypes in the present study.Conclusion: Our results emphasize the importance of considering ethnic background in assessing the etiological significance of candidate genes in osteoporosis.
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