Abstract
This study investigates the curative response of ethanol extract of Cassia sieberiana leaves (EECSL) on testosterone-induced benign prostatic hyperplasia (BPH). Thirty rats (120-160 g) were grouped into six of five rats each. Group 1 was the normal control; groups 2-6 were induced with testosterone (5 mg/kg body weight) for twenty-one days following standard procedures. Group 2 serves as BPH-control, groups 3 received finasteride while 4-6 received orally 100, 300, and 500 mg/kg of EECSL respectively for 14 days. Biochemical and BPH indices were analyzed. Oral administration of EECSL showed a decrease in prostate weight, Prostate specific antigen (PSA), testosterone and dihydrotestosterone (DHT), triacylglycerol (TAG), total cholesterol (TC), low density lipoprotein (LDL), malondialdehyde (MDA), aspartate aminotransferase (AST) alanine aminotransferase (ALT) whereas an elevation in High density lipoprotein (HDL), GSH and likewise antioxidant enzymes superoxide dismutase (SOD) and catalase (CAT) activities were recorded. The histology photomicrograph showed that EECSL restored lesions of testosterone induction in the treated groups. Our study reveals that EECSL exerts potent on BPH, hypolipidaemic, and antioxidant potentials and justifies the claims by the traditional doctors in BPH management.
Highlights
Prostate disorders are pathological disease that causes inflammation and mass enlargement of the prostatic epithelial and stromal cells which causes proliferation and death of prostate cells
A significant increase was recorded in the final body weight of the animals in comparison to their initial weight
Similar trend was observed by Park et al, (2017) which reported a non-significant elevation in the body weight gain of experimentally induced benign prostatic hyperplasia (BPH) animals compared to the normal control
Summary
Prostate disorders are pathological disease that causes inflammation and mass enlargement of the prostatic epithelial and stromal cells which causes proliferation and death of prostate cells. Dutasteride are the target drugs of choice for the management of BPH. Increase the use of alternative ways for the treatment and management of BPH is sought after. In Nigeria, extracts of C. sieberiana plant have been used in folklore for the treatment of tooth pain, icterus, inflammation, weakness of the bones and joints (Sam et al, 2011). The plant leaf extract has been reported to be rich in phytochemical constituents and exhibits antibacterial and anti-inflammatory activity (Donkor et al, 2013). Its leaf extract decoction is used traditionally to manage BPH with no documentation in scholarly literature. Our study aimed at investigating and to validate the potent of EECSL on testosterone-induced BPH in experimental animals
Sign-in/Register to view highlights & summary Talk to us
Join us for a 30 min session where you can share your feedback and ask us any queries you have
Schedule a callDisclaimer: All third-party content on this website/platform is and will remain the property of their respective owners and is provided on "as is" basis without any warranties, express or implied. Use of third-party content does not indicate any affiliation, sponsorship with or endorsement by them. Any references to third-party content is to identify the corresponding services and shall be considered fair use under The CopyrightLaw.
