Abstract
Present study was undertaken to estimate and compare erythrocyte superoxide dismutase (E-SOD) and Glutathione peroxidase (GPx) levels in oral submucous fibrosis, oral leukoplakia and oral cancer patients and age/sex matched healthy subjects, 25 in each group. Statistically significant (P<0.001) decrease in E-SOD and GPx levels were observed in OSF, oral leukoplakia and oral cancer groups as compared to the control group. Oral leukoplakia group showed lower levels in comparison with OSF (P>0.05). Oral cancer group had the lowest levels amongst the study groups. Imbalance in antioxidant enzyme status may be considered as one of the factors responsible for the pathogenesis of cancer and may serve as a potential biomarker and therapeutic target to reduce the malignant transformation in oral premalignant lesions/conditions.
Highlights
Oral squamous cell carcinoma (OSCC) is one of the most common cancers in the world, often preceded by specific premalignant lesions or conditions, the most common amongst them are the Oral Leukoplakia and Oral Submucous Fibrosis
Significant (P
Control groups consisted of 25 healthy, age/sex matched subjects (Control A) for OSF and oral leukoplakia; and another control group (Control B) for oral cancer
Summary
Shubha Gurudath1*, KS Ganapathy, Sujatha D1, Anuradha Pai, Sushmini Ballal, Asha ML2
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