Estimation of some immunological markers for patients with Hepatitis C and B viruses with β -thalassemia major in Babylon province

Abstract

Hepatitis C, B is a severe public health problem worldwide. Thalassemia patients depend on blood transfusions throughout and are at high risk of viral infections. This study aimed to estimate the prevalence of hepatitis C infection and different clinical parameters of (HLA) in the multiplex thalassemia population. In this study, 66 patients with infectious complications beta-thalassemia were enrolled, and samples collected from the Genetic Hematology Center at Babel Women and Children Hospital in Babylon Governorate / Iraq infected with HCV, serum ferritin, PCV and splenectomy were analyzed. The overall prevalence of hepatitis B virus and HCV was 3% and 55%, respectively; 100% of patients over 10-20 years of age had hepatitis C infection, and some episodes were presented by different HLA molecules, by molecule HLA from HLA class II (HLA-DR) and HLA class I (HLAG), In this study, we review the role of the molecule and several parameters along the HLA-G and HLA-DR gene in viral hepatitis, studies of hepatitis suggest that even Human leukocyte antigen contributes to the pathogenesis of the disease. HLA classification combined with the study of the regulatory elements of genes may help understand the influence of genetic background on susceptibility to disease. Keywords: Detection of some immunological markers (HLA) for hepatitis patients and those with a previous infection with thalassemia