Abstract
The study presented in this article involves the estimation of the overall heat transfer coefficient of cooling system in RF capacitive hyperthermia treatment using inverse problem based on the conjugate gradient method to provide improved distribution of temperature. The temperature data computed numerically from the direct problem using the finite difference time domain method are used to simulate the temperature measurements. The effects of the errors and sensor positions upon the precision of the estimated results are also considered. The results show that a reasonable estimation of the unknown can be obtained. Finally, measurements in a tissue-equivalent phantom are employed to appraise the reliability of the presented method. The comparison of computed data with measurements shows a good agreement between numerical and experimental results.
Highlights
Hyperthermia is the procedure to raise the temperature of tumor-loaded tissue to 40 ̊C - 43 ̊C and it is applied as an adjunctive therapy with various established cancer treatments such as radiotherapy and chemotherapy [1]
The study presented in this article involves the estimation of the overall heat transfer coefficient of cooling system in RF capacitive hyperthermia treatment using inverse problem based on the conjugate gradient method to provide improved distribution of temperature
We demonstrate that optimum heating conditions inside the phantom can be numerically attained by means of estimation of the overall heat transfer coefficient (OHTC) associated with the cooling system
Summary
Hyperthermia is the procedure to raise the temperature of tumor-loaded tissue to 40 ̊C - 43 ̊C and it is applied as an adjunctive therapy with various established cancer treatments such as radiotherapy and chemotherapy [1]. The effect of the water coupling bolus on the temperature and the specific absorption rate (SAR) of tissue during hyperthermia treatment have been the main themes of a number of studies [2,3]. Sherar et al [8] presented the design of a water bolus for external microwave applicators which increased the available treatment field size by removing the central hot spot caused by the increased power from the applicator in this region. They used beam shaping bolus with array of saline-filled patches inside the coupling water bolus for superficial microwave hyperthermia [9]. The Levenberg-Marquardt and simplex methods are common techniques for solving
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