Abstract

1 Department of Mathematics and Statistics, University of Melbourne, VIC 3010, Australia g.qian@ms.unimelb.edu.au 2 Department of Statistics, Penn State University, University Park, PA 16802, U.S.A. crr1@psu.edu 3 Department of Mathematics and Statistics, York University, 4700 Keele Street, Toronto, Ontario, M3J 1P3, Canada wuyh@yorku.ca 4 Biostatistics and Statistical Reporting, One Health Plaza, Bldg. 435 4173, Novartis Pharmaceuticals Corporation, East Hanover, NJ 07936, U.S.A. qing.shao@novartis.com

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