Abstract
Synthesis of esters of 1- and 3-hydroxyquinolizidine as well as of the parent aminoalcohols is described, and preliminary screening suggests that antispasmodic activity is enhanced by the beta-arrangement. Suitable esters of all three aminoalcohols have also been synthesized to determine the degree of local anesthetic activity associated with them. A significant degree of inhibition of spontaneous motor activity in rats was noted with the trimethoxybenzoates of 1- and 3-hydroxyquinolizidine.
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