Abstract
The aim of this study was to develop erythrosine-loaded electrospun polyvinyl pyrrolidone/ hydroxypropyl-β-cyclodextrin (PVP/HPβCD) fiber patches for plaque disclosing. The fiber patches had been fabricated via electrospinning process and were characterized using scanning electron microscope (SEM), Fourier transform infrared spectrophotometry (FT-IR), differential scanning calorimeter (DSC) and powder X-ray diffractometry (PXRD). The fiber patches were then further evaluated for wetting and integration abilities, mechanical properties, loading efficiency, loading capacity and release characteristic. These erythrosine-loaded fiber patches exhibited excellent wetting and disintegration properties and prompt released the erythrosine form the patches after contacted with saliva. These erythrosine-loaded fiber patches could be exploited as a plaque-disclosing material. However, further in vivo studies are needed for the application.
Highlights
Dental plaque is a biofilm composed of a complex microbial community [1,2]
Dental plaque consists of carbohydrates and proteins which act as reservoir of nutrient and promote the adherence of the biofilm to the enamel
The use of disclosing agent encourages an individual in the early removal of dental plaque by showing the presence and quantity of plaque [4, 5]
Summary
Dental plaque is a biofilm composed of a complex microbial community [1,2]. Most people do not recognize the quantity and the location of the plaque existing in the mouth because dental plaque is usually transparent, colorless and not visible. Recognition of this difficulty has led to the launch of disclosing agents [5]. The use of disclosing agent encourages an individual in the early removal of dental plaque by showing the presence and quantity of plaque [4, 5]. Erythrosine, a water-soluble dye, has been widely used to detect the plaque
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