Abstract
Erythema multiforme (EM) is an acute, self-limiting, mucocutaneous disease. While the histopathologic and immunopathologic feature of EM is not highly specific, the diagnosis is mainly based on the etiology and clinical manifestations. This report presented a patient whose clinical investigation indicated EM while histopathology suggested lichenoid mucositis. Considering the classic oral and skin presentation matching EM, as well as the acute onsite and spontaneous resolution of the lesions, the diagnosis highly favored EM. The immunofluorescent findings might suggest a potential common pathologic process on EM and lichenoid mucositis, which requires further investigation.
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