Abstract
Erythema multiforme (EM) is an acute, self-limiting, mucocutaneous hypersensitivity reaction characterized by distinctive target lesions. Most cases have been attributed to infection. EM occurs mainly in young adults and is extremely rare during the neonatal period. We report an 11-day-old boy who presented with target skin lesions on upper limbs and lower limbs with no other associated symptoms. He had no remarkable maternal, birth, or past medical history. Complete blood count, chest radiography, and herpes simplex virus 1 and 2 immunoglobulin G titers revealed no abnormalities. Urine analysis showed fungal hyphae and culture grew candida albicans. Lesions disappeared after starting antifungal. Pathologic examination showed vacuolar interface change and dyskeratotic cells in the epidermis consistent with EM. This unusual case emphasizes the importance of recognizing diagnostic clues in examining patients.
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