Abstract
Equilibria and kinetics for reactive extraction of pranoprofen (PRA) enantiomers with methyl-β-cyclodextrin (Me-β-CD) in water as diluent were reported. The theory of extraction accompanied by a chemical reaction has been used to obtain the kinetics. The reactions between Me-β-CD and PRA enantiomers fall in Regime 3. The reactions are first order with respect to PRA and second order with respect to Me-β-CD. The forward rate constants are 2.82×10−4m6/(mol2s) for S-PRA and 3.53×10−4m6/(mol2s) for R-PRA, respectively. The developed extraction model is suitable to analyze and evaluate the reactive extraction of PRA enantiomers by Me-β-CD.
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