Abstract
Two different nucleic acid hybridization techniques were used to search for Epstein-Barr virus (EBV) DNA in four human lymphoma-derived cell lines of B lymphocyte type: BJAB, Ramos, U-698 M, and U-715 M. These cell lines do not express an EBV-associated nuclear antigen, EBNA. Four stably EBNA-positive sublines, GC-BJAB, AW-Ramos, EHRA-Ramos, and EHRB-Ramos, obtained by exposure of the parent lines BJAB and Ramos to EBV in vitro, were also investigated. The EBNA-negative cell lines did not have detectable amounts of EBV DNA (less than 0.3 EBV genome per cell), while the EBNA-positive sublines contained EBV DNA sequences. However, two of the latter four lines had much less EBV DNA (0.8–2 viral genome equivalents per cell) than typical human lymphoid cell lines.
Sign-in/Register to access full text options 
Talk to us
Join us for a 30 min session where you can share your feedback and ask us any queries you have
Schedule a callDisclaimer: All third-party content on this website/platform is and will remain the property of their respective owners and is provided on "as is" basis without any warranties, express or implied. Use of third-party content does not indicate any affiliation, sponsorship with or endorsement by them. Any references to third-party content is to identify the corresponding services and shall be considered fair use under The CopyrightLaw.
