Abstract
Objectives: Basic science results suggest that abnormalities of the endocrine pancreas in cystic fibrosis (CF) occur earlier than was believed so far. All stages of the spectrum of glucose metabolism disorders are associated with increased morbidity and mortality which could be reduced by early recognition and treatment. However, screening for abnormal glucose tolerance (AGT) is recommended only from the age of 10 according to the actual guidelines. We conducted a systematic review and meta-analysis on the prevalence of abnormal glucose tolerance in patients with CF with a focus on children under 10 years of age.
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