Abstract
Immunoglobulin A (IgA) and G (IgG) were analyzed in rat plasma, uterus and uterine secretions by radioimmunoassay and in tissues by immunofluorescent microscopy to determine the mechanism by which estradiol controls IgA and IgG movement from the uterus into the uterine lumen. To determine whether there was evidence for immunoglobulin transport, plasma, tissue and uterine fluid concentrations of IgA and IgG were measured in ovariectomized rats at a time when uterine fluid IgA and IgG were elevated by treatment with estradiol. The concentration of IgA in uterine fluid was 22 times greater than that in tissue indicating that, in response to estradiol, IgA accumulated in the lumen against an apparent concentration gradient. In contrast to IgA, the concentration of IgG in uterine fluid was significantly lower than that in the uterus and in plasma.
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