Abstract

Epigenetics as a field of study is important because it tends to give answers to pertinent questions like why are identical twins behaving differently despite their possession of the same gene? Epigenetics provides a frame work for solving medical problems like mental retardation, neurodegenerative disorder, schizophrenia and social challenges like suicide and addiction. Abnormal DNA methylation pattern in epigenetics has been linked with a huge number of human cancers. However, recent research has revealed that epigenetic pharmaceuticals like vorinostat, decitabine and azacytidine could be a replacement or aid therapy for presently accepted treatment methods such as radiation and chemotherapy or may argument these current treatments. Understanding epigenetics phenomena entails the use of some research methods which include chromatin immunoprecipitation, fluorescent in-situ hybridization, methylation-sensitive restrictive enzyme and the use of bioinformatics methods. Further research work into epigenetics should be encouraged since this discipline of study has the potential to unravel lots of knowledge that will be very beneficial to managing some medical conditions.

Highlights

  • Epigenetics is defined as the study of heritable changes in gene activities which are not due to changes in Deoxyribonucleic acid (DNA) sequences

  • Unlike simple alterations to the DNA sequence, the changes in gene expression of epigenetics are caused by other means- the use of the term epi-(Greek epi- over, outside, around) genetics.[3]

  • Examples of mechanisms that result in such alterations are DNA methylation and histone modification each of which causes changes on how genes are expressed without effecting a change in the underlying DNA sequence.[4,5,6]

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Summary

Introduction

Epigenetics is defined as the study of heritable changes in gene activities which are not due to changes in Deoxyribonucleic acid (DNA) sequences. 7,8 These epigenetic alterations are able to last through cell divisions for the period of the cell’s life span They are capable of lasting for multiple generations even though there are no accompanied changes in the underlying DNA sequence of the organism; rather non-genetic factors lead to different behavior of the organism’s genes.[3,4,9] Epigenetics often denotes alterations in a chromosome that influence gene activity and expression, but is used to explain any heritable phenotypic alterations that do not originate from modification of the genome like the prions. Even if they have the same diet and lifestyle, unnoticeable cultural and environmental distinctions appear to change their phenotype.[11]

Molecular Basis of Epigenetics
Techniques used to Study Epigenetics
Behavioral Epigenetics
Pyschopathology and Mental Health in Epigenetics
Epigenetics of Schizophrenia
Further Examples of Effects of Epigenetics
Epigenetics and Cancer
Epigenetics and Cancer Treatment
Conclusion

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