Abstract
THE loss of tissue-specific antigens, which has been considered to be important in neoplastic behaviour1–3, occurs in both experimental and human tumours, including squamous cell carcinomas of human4,5 and murine6 origin. Techniques used to demonstrate antigen deletion have involved heterologous anti-tissue sera or naturally occurring organ-specific auto-antibodies. Among the latter, the discovery of anti-skin activity in the sera of human subjects with the skin diseases pemphigus vulgaris7 and bullous pemphigoid8 has provided reagents for the demonstration of antigenic change in experimental skin dysplasia and neoplasia.
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