Epidenic study of high-risk human Papillomavirus cervix infection among women in Yantai city

Abstract

Objective To investigate high risk human papillomavirus (HR-HPV)infection of women in Yantai and establish the epidemic data of HR-HPV infection in the area.Methods A total of 3690 gynecological outpatients from March 2009 to June 2011 were involved,21 types of HPV DNA including 13 HR-HPV types were detected with women's cervical scrapes by PCR amplification,flow-through hybridization and gene chip technology,and 445 volunteers were detected by colposcopic biopsy.Results In 3690 patients,721 women were HPV positive( 19.54％ )and 622 patients were HR-HPV infection( 16.86％ ).In HR-HPV patients,426 patients were single infection and 196 were multiple infection.HPV16,58,52 prevalence rates were 30.06％,17.36％ and 16.40％,significant differences were found in both infection rate of HR-HPV ( x2 =617.447,P ＜ 0.01 ) and multiple infection rate ( x2 =28.045,P ＜ 0.01 ) among HR-HPV genotypes.The patients were classified into 5 age groups:≤20,21-30,31-40,41-50 and＞ 50 year-old,according to the age groups.HR-HPV prevalence rates were 21.88％,18.67％,15.63％,15.26％ and 17.05％ respectively.There were no statistical differences in 5 age groups( x2 =6.692,P ＞ 0.05).HR-HPV prevalence rates of different quarters were 17.81％,17.05％,16.67％ and 15.92％ (x2=1.141,P ＞ 0.05).HPV16 was the priority HR-HPV type in the pathological groups.Conclusions HPV16 was the predominant type followed by HPV 58 and 52 in Yantai area.HR-HPV infection rate showed a double peak characteristics in different age groups.HPV16 type played an important role in the occurrence of cervical cancer. Key words: Papillomaviridae; Genotype; Cervical carcinoma; Epidemiology