Epidemiology of Pre-Adolescent Hospitalizations for Suicidal Thoughts and Behaviors.

A Suicide-Specific Diagnosis – The Case Against

Suicidal thoughts and behaviors (STBs) are a public health concern, particularly among Veterans, who experience elevated rates of STBs. Social integration is negatively associated with STBs, such that high social integration is correlated with low rates of STBs. Much of the literature has studied marital status as a social relationship that may protect individuals from STBs. Although largely unstudied, it has long been assumed that social integration moderates the link between marital status and STBs. Thus, in a sample of Veterans (N = 1469; Military Health and Well-Being Project), we tested our hypotheses that (1) social integration varies by marital status (single vs. married vs. domestic partnership vs. divorced vs. widowed), (2) social integration is negatively associated with STBs (i.e., lifetime suicidal ideation, past year suicidal ideation, suicidal ideation communication, and likelihood of suicide attempt), (3) STBs vary based on marital status, and (4) social integration moderates the cross-sectional link between marital status and STBs. Results indicated that (1) marital status was associated with social integration, such that married people reported greater social integration than people who were single; (2) social integration was negatively associated with all four STBs (r's < - 0.09, p < 0.001); (3) STBs varied based on marital status such that married people reported fewer STBs than people who were in a domestic partnership, single, widowed, or divorced, and (4) social integration did not moderate the link between marital status and STBs. Findings indicate that factors external to marital status may contribute to the link between social integration and STBs.

Interoceptive Accuracy, Sensitivity, and Attention are Associated with Suicidal Thoughts and Behaviors.

Data from high-income countries (HICs) show a high risk of suicidal thoughts and behaviors (STBs) in first-episode psychosis (FEP). It is unknown, however, whether rates and associated factors differ in low- and middle-income countries (LMICs). We therefore aimed to compare the 2-year course of STBs and associated factors in persons with FEP treated in two similarly structured early intervention services in Chennai, India and Montreal, Canada. To ensure fit to the data that included persons without STBs and with varying STBs' severity, a hurdle model was conducted by site, including known predictors of STBs. The 2-year evolution of STBs was compared by site with mixed-effects ordered logistic regression. The study included 333 FEP patients (168 in Chennai, 165 in Montreal). A significant decrease in STBs was observed at both sites (OR = 0.87; 95% CI [0.84, 0.90]), with the greatest decline in the first 2 months of follow-up. Although three Chennai women died by suicide in the first 4 months (none in Montreal), Chennai patients had a lower risk of STBs over follow-up (OR = 0.44; 95% CI [0.23, 0.81]). Some factors (depression, history of suicide attempts) were consistently associated with STBs across contexts, while others (gender, history of suicidal ideation, relationship status) were associated at only one of the two sites. This is the first study to compare STBs in FEP between two distinct geo-sociocultural contexts (an HIC and an LMIC). At both sites, STBs reduced after treatment initiation, suggesting that early intervention reduces STBs across contexts. At both sites, for some patients, STBs persisted or first appeared during follow-up, indicating need for suicide prevention throughout follow-up. Our study demonstrates contextual variations in rates and factors associated with STBs. This has implications for tailoring suicide prevention and makes the case for more research on STBs in FEP in diverse contexts.

Trajectories of Suicidal Thoughts and Behaviors From Preschool Through Late Adolescence.

Background: Suicide is the second leading cause of death among youth aged 10 to 14 years and third for those aged 15 to 24 years in the United States and in Ohio. Suicidal thoughts and behaviors disparately affect youth with oppressed identities, including those with oppressed racial, ethnic, gender, and sexual minority identities. The purpose of this study was to examine the relationship between self-reports of suicidal thoughts and behaviors among Ohio youth with oppressed identities. This research also contextualizes relationships between these indicators through the context of intersectionality. Methods: This cross-sectional descriptive study used responses from the 2019 Ohio Youth Risk Behavior Survey (YRBS; n = 1263) to examine the relationships between identity variables and suicidal thoughts and behaviors through a series of logistic regression models. Results: Female youth have higher odds of reporting persistent feelings of sadness and hopelessness and seriously considering suicide than male youth. Lesbian, gay, or bisexual (LGB) youth have higher odds of reporting all outcome measures of suicidal thoughts and behaviors (STBs), and youth with oppressed racial and ethnic identities were in general more likely to report higher odds of STBs when compared to White youth. Conclusion: Suicidal thoughts and behaviors disparately affect youth with these oppressed identities. Our findings suggest further examination of these youth nationally may influence public health suicide prevention strategies. Implica-tions also suggest that researchers, practitioners, and organizations across the spectrum of youth suicide prevention in Ohio should understand the increased risk that youth with multiple, intersectional oppressed identities face for suicide.

Objective: Examine the relationship between internalized stigma, experiential avoidance (EA), and suicidal thoughts and behaviors (STBs) in a sample of college students, and explore whether EA accounts for part of the relationship between internalized stigma, EA, and STBs. Participants: College students (N=78) completed online questionnaires about demographic information, internalized stigma, EA, and STBs. Results: A simple mediation model evaluated the indirect effect of internalized stigma on STBs through EA, controlling for the presence of a mental health disorder diagnosis. Results: Internalized stigma, STBs, and EA were all positively correlated. EA partially mediated the relationship between internalized stigma and STBs. Conclusion: Despite decades of research and prevention efforts, STBs remain a pervasive problem. There is an urgent need to identify modifiable predictors of STBs. Internalized stigma is a risk factor for STBs, and recent research suggests EA might be a mechanism linking internalized stigma and STBs. Our findings suggest EA might represent a modifiable mechanism of change in the context of both anti-stigmatization and suicide prevention programs.

Suicidal Thoughts and Behaviors in Elementary School–Aged Youth: A Pilot Study in 5- to 10-Year-Olds

Preschool-Onset Major Depressive Disorder as a Strong Predictor of Suicidal Ideation and Behaviors Into Preadolescence

Child suicide rates and emergency department visits due to suicidal thoughts and behaviors (STB) are rising at an alarming rate globally. In the United States, suicide deaths among children aged 5-12 increased by 195% from 1990 to 2020, highlighting an urgent need for greater understanding of the underlying risk factors. Although poor parent-child relationships and child emotional dysregulation have been identified as correlates of STB, the precise mechanisms linking these factors remain insufficiently explored. This study aimed to examine the associations between insecure attachment styles (anxious and avoidant), emotional dysregulation and STB in children. Grounded in attachment theory, it was hypothesized that emotional dysregulation would mediate the relationship between insecure attachment and STB. A sample of 111 children aged 7-12, admitted to a pediatric emergency department (ED) for STB, completed self-report measures assessing attachment styles (ECR-RC), emotional dysregulation (DERS), and STB (C-SSRS). Cross-sectional mediation regression analyses revealed that emotional dysregulation significantly mediated the relationship between anxious attachment and suicidal behaviors. However, no mediation effect was found between avoidant attachment and suicidal thoughts. These findings suggest that children with anxious attachment styles are particularly vulnerable to experiencing emotional dysregulation associated with suicidal behaviors. The absence of a similar mediation effect for avoidant attachment and suicidal thoughts may point to distinct psychological pathways underlying different forms of STB. These results highlight the potential importance of targeting the parent-child relationship to enhance children's emotional regulation abilities, which may, in turn, reduce the risk of suicidal behaviors.

Despite very high rates of suicidal thoughts and behaviors (STB) in autistic adults, the key psychosocial drivers of this phenomenon remain unknown. To investigate, we examined how lifetime stressor exposure and severity, which have been found to predict STB in non-autistic populations, related to STB in a multinational dataset of 226 autistic adults from the United Kingdom and Australia (67% female; Mage = 41.8, SD = 13.6, range = 19–73 years old). Results revealed that autistic men and women differ with respect to the count, severity, and type of stressors they experienced over the life course. Whereas autistic men were exposed to more numerous legal/crime-related stressors, autistic women experienced more stressors related to social relationships and chronic humiliation and typically experienced stressors as more severe. In addition, whereas chronic interpersonal loss was related to STB for men, acute stressors involving physical danger and lower exposure to chronic entrapment were related to STB in autistic women. These findings indicate that certain lifetime stressors may be differentially experienced, and relevant to STB, in autistic men versus women. They also suggest that screening for lifetime stressor exposure may help identify autistic individuals at greatest risk of suicide.Lay abstractWhen we encounter life events that we experience as stressful (“stressors”), it sets off a biological stress response that can impact mental health and contribute to suicidal thoughts and behaviors (STB). Although we know about specific stressors that are associated with STB in the general population, little is known about the kinds of stressors that increase the risk of STB in autistic people and whether these associations differ by gender. To examine this issue, we cataloged the life stressors that autistic men and women experienced over the entire life course and investigated how these stressors were related to STB. Data were derived from a multinational sample of 226 autistic adults from the United Kingdom and Australia who completed the Stress and Adversity Inventory for Adults. We found that autistic men and women differed in terms of both the lifetime stressors they experienced as well as their perceived severity. Whereas men experienced more legal/crime-related stressors, women experienced more stressors related to relationships with other people and more long-lasting stressors associated with humiliation. Autistic women often perceived life stressors as more severe than men, which is important given that it is the perceived severity of stressors that most strongly affects our health. We also found that different stressors may predict STB in autistic men versus women. Whereas loss of loved ones was most strongly associated with STB for men, for women, physically dangerous stressors were most relevant. In addition, women with fewer lifetime stressors involving entrapment had higher lifetime STB. These results suggest that lifetime stressor exposure may be important to assess to understand suicide risk in autistic people. Additional research is needed to confirm these associations and to examine possible mechanisms linking stress and STB.

Grit, humor, and suicidal behavior: Results from a comparative study of adults in the United States and United Kingdom

Background: Previous studies suggest that selective serotonin reuptake inhibitors (SSRIs) may increase the risk of suicide among children and youth, although the association between suicide risk and the combination of SSRIs with other medication such as stimulants in this population remains unclear. This study explored whether the combination of SSRIs with stimulants influenced suicide risk. Methods: A retrospective cohort study was conducted at a single children's hospital campus-based ambulatory psychiatric clinic between September 1, 2017, and September 30, 2020. Subjects were 6-21 years of age and prescribed either stimulants or stimulants and SSRIs only. The primary outcome was suicidal thoughts and behaviors (STB), defined by documented suicidal thoughts, plans, or behaviors. Firth logistic regression evaluated associations between medication class and STB. Results: Among 349 patients, the prevalence of STB was 5.7% (n = 20). In unadjusted model, patients prescribed SSRIs and stimulants had a 2.9-fold increase of STB compared to patients prescribed stimulants only, along with increasing age, male sex, and the diagnoses of anxiety and/or depression. In the final model adjusted for each of these factors, the observed association of medication regiment with STB was attenuated (odds ratio [OR]: 1.3, confidence interval [CI]: 0.3-4.9, p = 0.7). The magnitude of the adjusted association between depressive diagnosis and STB was notable (OR: 3.6, CI: 1.0-12.6, p = 0.049). Conclusions: Among patients followed in a children's hospital-based ambulatory psychiatric clinic, a combination medication regimen of SSRIs and stimulants after adjusting for genetic sex, age, anxiety diagnosis, and depression diagnosis, the observed association between STB and combination stimulant and SSRI treatment was attenuated. This finding suggests that other factors, including depression, may have contributed to the association between SSRI treatment and STB. Larger, prospective studies of the relationship between combination pharmacotherapy and suicide risk are warranted to guide clinical/pharmacological decision making and to better clarify these relationships.

Recent theories have implicated inflammatory biology in the development of psychopathology and maladaptive behaviors in adolescence, including suicidal thoughts and behaviors (STB). Examining specific biological markers related to inflammation is thus warranted to better understand risk for STB in adolescents, for whom suicide is a leading cause of death. Participants were 211 adolescent females (ages 9-14 years; Mage = 11.8 years, SD = 1.8 years) at increased risk for STB. This study examined the prospective association between basal levels of inflammatory gene expression (average of 15 proinflammatory mRNA transcripts) and subsequent risk for suicidal ideation and suicidal behavior over a 12-month follow-up period. Controlling for past levels of STB, greater proinflammatory gene expression was associated with prospective risk for STB in these youth. Similar effects were observed for CD14 mRNA level, a marker of monocyte abundance within the blood sample. Sensitivity analyses controlling for other relevant covariates, including history of trauma, depressive symptoms, and STB prior to data collection, yielded similar patterns of results. Upregulated inflammatory signaling in the immune system is prospectively associated with STB among at-risk adolescent females, even after controlling for history of trauma, depressive symptoms, and STB prior to data collection. Additional research is needed to identify the sources of inflammatory up-regulation in adolescents (e.g., stress psychobiology, physiological development, microbial exposures) and strategies for mitigating such effects to reduce STB.

Objective Understanding patterns of suicide risk over the course of development can aid our ability to prevent suicide. Our community-based study examined changes in suicide risk status and predictors of changes in risk status in a sample of 521 adolescents over six assessments between the start of middle school and young adulthood (ages 12–22). Methods Suicidal thoughts and behaviors (STB) were measured with the Diagnostic Interview Schedule for Children and the Moods and Feelings Questionnaire. Latent transition analysis (LTA) was utilized to evaluate transitions in suicide risk status over the course of development. Nine risk factors’ initial values and change over time were modeled as predictors in the LTA. Results Latent class analysis identified a four-class model of developmental suicide risk patterns: Class 1: Infrequent STB (73–87% of participants), Class 2: Diminishing STB (1–17% of participants), Class 3: Escalating STB (6–16% of participants), and Class 4: Consistently High STB (1–5% of participants). LTA demonstrated that infrequent STB members and escalating STB members were likely to maintain their risk class across time points. Conclusions Classification of STB trajectories demonstrated self-worth and family involvement were salient variables affecting transitions in risk over time and suggest prevention targets early in adolescence that could have impact on suicide risk in adulthood.