Abstract
The study aimed to explore the epidemiology and clinical characteristics of chronic osteomyelitis observed in a northern China hospital. Clinical data of 255 patients with chronic osteomyelitis from January 2007 to January 2014 were collected and analyzed, including general information, disease data, treatment and follow-up data. Chronic osteomyelitis is more common in males and in the age group from 41–50 years of age. Common infection sites are the femur, tibiofibular, and hip joint. More g+ than g- bacterial infections were observed, with S. aureus the most commonly observed pathogenic organism. The positive detection rate from debridement bacterial culture is 75.6%. The detection rate when five samples are sent for bacterial culture is 90.6%, with pathogenic bacteria identified in 82.8% of cases. The two-stage debridement method (87.0%) has higher first curative rate than the one-stage debridement method (71.2%). To improve detection rate using bacterial culture, at least five samples are recommended. Treatment of chronic osteomyelitis with two-stage debridement, plus antibiotic-loaded polymethylmethacrylate (PMMA) beads provided good clinical results in this study and is therefore recommended.
Highlights
Chronic osteomyelitis is a common clinical disease and a challenging disorder, characterized by its long disease course, difficult early diagnosis and high disability rate
Our study showed that chronic osteomyelitis is more common in males and in the age group from 41–50 years of age
More g+ than g- bacterial infections were observed, with S. aureus the most commonly observed pathogenic organism
Summary
Chronic osteomyelitis is a common clinical disease and a challenging disorder, characterized by its long disease course, difficult early diagnosis and high disability rate. The clinical characteristics of chronic osteomyelitis are varied, and may be affected by geography, time, and pathogenetic differences. Multiple injuries are difficult to treat and frequently lead to infection; treatment exerts great pressures on patients, both economically and psychologically. It poses great challenges for orthopedists[7]. Data and relevant research are lacking for northern China on the epidemiology of chronic osteomyelitis. We conduct an epidemiological statistical analysis on 255 patients at a prominent hospital and explore the clinical characteristics of chronic osteomyelitis in northern China
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